970464 - Scientist / Senior Scientist, Cytometry - Groton, CT (New London/Norwich, CT Area)

*Please apply @ www.pfizercareers.com*

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide. 

Role Description 
Responsible for the development of flow cytometry and imaging cytometry methods and generation of cellular biomeasures and biomarker data in support of therapeutic targets in the areas of oncology, inflammation and cardiovascular medicine from early discovery to Ph1 clinical trials. Provide expertise in flow cytometry and cell imaging technologies in matters such as phenotyping, activation markers, cell signaling, receptor internalization and occupancy. Experience in cell based assays, mechanistic pharmacology, target evaluation, target assessment, and translational biomarker is desirable. Candidate will participate with PDM teams and research units in a matrix environment. Should have proven experience in flow and cell imaging-based biomarkers in animal and clinical studies, and have strong knowledge of biological systems and cellular function to enable Pfizer discovery and development objectives. 

Responsibilities 
•The successful candidate will have experience developing partnerships in a matrix environment, influencing project strategies, and participate in technology development and implementation.
•Other responsibilities include independent planning of laboratory activities, understanding and influencing therapeutic area biomarker strategies to use biomarkers in scientific decision-making. 
•Candidate will participate in all phases of FACs laboratory operations including technology evaluations, the protocol development, separation and detection methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
•Proactively gathers input from colleagues, teams & management to avoid/address issues at functional level and participates on cross discipline matrix teams 
•Provide technical training/mentorship for FACs scientists
•Excellent oral/written communication skills
•Demonstrated ability to clearly & concisely communicate bioanalytical information
•Understanding of "fit-for-purpose" assay development and support. Ability to effectively balance assay rigor against resource needs and study goals 

Equal Employment Opportunity 
Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Pfizer in the U.S. In certain circumstances it may be advantageous to Pfizer to support the application(s) for temporary visa classification and/or sponsor applications for permanent residence so that a foreign national colleague can accept or remain in a work assignment in the U. S. For certain classes of temporary visas, the resulting work authorization may be specific to Pfizer and the specific job and/or work site. Pfizer may at its business discretion decide to or refrain from obtaining, maintaining and/or extending the temporary visa status and/or sponsoring a colleague for permanent residency and /or employment eligibility, considering factors such as availability of qualified U.S. workers and the colleague's long-term prospects for securing lawful permanent residence, among other reasons. Employment applicants requiring immigration sponsorship must disclose, when initial application for employment is made, whether or not they are legally authorized to work for Pfizer in the U.S. and, if so, whether that authorization permits them to work in the job they seek. In no case should Pfizer's support of a colleague's temporary visa application or sponsorship of a colleague for permanent residence be construed to guarantee success of that application or amend or otherwise invalidate the "at-will" employment relationship between the colleague and Pfizer.

Qualifications 
EDUCATION AND EXPERIENCE
B.S. (>6 years), M.S. (>4 years), or Ph.D. (>0-2 years) in relevant scientific field with industrial experience. Experience in development, characterization, and implementation of quantitative biomarker/biomeasures Flow Cytometry based bioanalytical assays and relevant sample preparation methods and instrumentation). Experience in the development, validation and use of immunoassays for biomarkers and pharmacokinetics beneficial. Experience in the development and use of cell based assays beneficial.

TECHNICAL SKILL REQUIREMENTS
*Experience and knowledge in operation of modern flow cytometry and associated data/LIMS systems
*Knowledge and application of immunoassay techniques as applied to flow cytometry.
*Knowledge and application of sample preparation methodologies as applied to flow cytometry techniques
*Good understanding of biochemistry, cellular biology and cell culture/cell based assays. 
*Ability to coach and mentor colleagues and influence in a matrix environment
Good written and oral skills