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PUCL Job#1091-Sr. Scientist โ€“ Assay Development & Pharmacology (High Content Imaging) Pfizer (10142014)

Title: Sr. Scientist – Assay Development & Pharmacology (High Content Imaging)

Job ID: 1003688

Location:  United States-Connecticut-Groton

 

Org Marketing  Statement

All over the world, Pfizer colleagues  are working together to positively impact health for everyone,  everywhere. Each position at Pfizer touches and contributes  to the success of our business and our world. That’s why, as one of the global leaders in the biopharmaceutical industry, Pfizer is committed  to seeking out inspired new talent who share our core values and mission of making the world a healthier place.

 

Role Description

As member of a group providing high content screening data, to support target identification and the in vitro pharmacology needs of the Research  Unit portfolios by working with drug discovery project teams. The focus will be to deliver strategic screen design, assay development/optimization, image analysis algorithms  and automated  data analysis to execute high content cell based assays in phenotypic  screening  and physiologically relevant systems.

 

Responsibilities

The successful  candidate  will be a member of a laboratory  with other lab scientists focused on high content phenotypic assay development by executing  single cell image analysis and high throughput  flow cytometry  assays supporting  the portfolios of multiple therapeutic  areas and scientific initiatives.   He/she will design, validate and deliver high quality in vitro screening  data from high content imaging and flow cytometry  based pharmacology screens to drive lead series identification, optimization  and drug candidate  selection. He/she may also provide oversight and take accountability for the delivery of high content pharmacology data provided by external Contract Research  Organizations. He/she will be asked to bring strategic insight into the screen design, ensuring robust decision-making that is appropriate  for the biological challenges  of phenotypic  assays and enables the investigation of molecular  mechanisms of actions.    He/she will serve as a project point of contact for the drug discovery project teams.  Applicants  must have a strong scientific background  in high content cell biology, computational image analysis and drug discovery data analysis.   The

candidate  will possess strong collaborative and written/verbal communication skills and a positive attitude to interact

with multiple partners (e.g. therapeutic  area teams, Chemistry  and Biology leads, Pharmacodynamic and Safety lines and Outsourcing vendors).    He/she should demonstrate personal leadership  within the group, scientific leadership

both at the bench and at computational data analysis, and be adept at multi-tasking. He/she will be expected to mentor more junior scientists in the group to drive team success.

 

Successful  candidates  will be expected to:

• Be an expert in high content phenotypic  in vitro assay execution  and data analysis

 

• Have experience  with physiologically relevant cell based assay formats (IPS cells, Human primary cells, 3D culture and microfluidic  platforms)

 

• Have experience  using high content 384/1536 plate based platforms and possibly High throughput  flow cytometry.

 

• Be skilled in assay development and optimization  and familiar with the use of robotics and automation  in the performance of screening

 

• Be proficient in computational image analysis and automated  data management  to apply appropriate  software to specific needs

 

• Possess excellent writing and communication skills to works with divers partners to achieve objectives

 

• Contribute to and lead local and global projects for High content phenotypic  screening

 

• Develop and implement  algorithms  for imaged based data analysis and data management

 

• Serve as a resource for biological  and drug discovery high content screening expertise

 

• Proactively  respond to project team needs to support molecular  mechanism  of action identification

 

• Support collaborative scientific  initiatives within and across partner lines as appropriate

 

• Build and maintain a ‘cutting edge’ awareness  of new technology  advances (cytof, NanoSIM,  superResolution…), computational modeling system developments, and scientific knowledge  in the field to apply these where possible to improve performance

 

• Mentor and develop less experienced  staff to drive team success

 

• Adopt a Continuous  Improvement mindset to improve quality, efficiency  and/or cost of processes  within the lab

 

• Promote Pfizer High content phenotypic  screening capabilities  and reputation through external publications  and presentations.

 

Qualifications

Training & Education:

• Minimum qualification  PhD or equivalent  with 4+ years of relevant experience  to drug discovery in biology, cell biology, and/or pharmacology.

 

Prior Experience:

• Prior experience  in a laboratory  working as part of a multi-disciplinary team focused on the discovery of novel therapeutic  agents.

 

• Experience  with in vitro high content phenotypic  assays, data analysis, QC, and visualization.

 

• Cell biology and physiologically relevant cell based assay experience  essential.

 

• Experience  with troubleshooting technical assays and protocols.

 

• Experience  in designing and developing  high content cell based assays and to identify opportunities for improvement in assay execution.

 

• Demonstration of excellent computer,  verbal and written communication skills.

 

• Demonstrated examples of personal and scientific leadership.

 

• Have a sustained  track record of delivering high quality data meeting the needs of teams.

 

• Experience  of successfully  interacting  with and meeting the needs of stakeholder  groups is essential as well as having a customer focus.

 

• Experience  of interacting  with other groups in related areas such as material management, automation  and informatics  is essential.

 

Equal Employment Opportunity

Pfizer is committed  to equal opportunity  in the terms and conditions  of employment  for all employees  and job applicants  without regard to race, color, religion, sex, sexual orientation,  age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable  national, state and local laws governing  nondiscrimination in employment  as well as work authorization and employment  eligibility verification requirements of the Immigration  and Nationality  Act and IRCA.   Pfizer is an E-Verify employer.

Compensation Information

Global Performance Plan Eligible            Global Performance Plan Target

Grade   008

Salary Ranges  Overtime  Eligible

Minimum           Midpoint       Maximum             Annual


$78300.00                                               $ 97700.00      $117400.00

 

 Internal Candidate

Business  Unit         Global R&D - USA

Department        PDM - NCE

Manager         Regis Doyonnas

Recruiter         Ada Anosike-Crichton

 

Additional  Offer Details:

 

Internal Candidates  Identified

Relocation  Package Available

Global Job (As Defined by Pfizer or Business Unit Policy).

Job is Eligible for an Employee  Referral Award (as defined by Local Guidelines)

Foreign nationals whose eligibility to work requires sponsorship  or maintenance of valid immigration  status may not be eligible for this position.

 

 Immigration and Work Authorization

All candidates  must already have, or be able to readily secure authorizations to live and work on an ongoing basis in the country where job is based.

Pfizer will assist candidates  who secure an offer with the application  and processing  for immigration  status and work authorization. Pfizer will assist immediate  family members in obtaining immigration  status to enable them to relocate with the employee.  In most cases, work authorization can only be obtained for the employee,  not for accompanying family members.

 

 https://jobs.pfizer.com/psc/recruit/EMPLOYEE/HRMS/c/LSYS_DEVELOPMENT.Z_PFIZER_JOBS.GBL?country=USA&languagecd=ENG

 

Management retains right to change the job specifications and provisions of this job as appropriate.

 

Please Note:

 

Your decision  whether  or not to post for an open position  has no impact on

your eligibility  for severance  benefit under the terms of any separation  policy or plan. All decisions  about severance  eligibility  will be made in accordance with terms of the applicable  policy or plans.

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