Senior / Principal Scientist, Cytometry & Biomarkers [PDM]
Andover, Massachusetts (Greater Boston Area)
Job 977680 - CLICK TO APPLY http://bit.ly/PFE_MA_CyTOF
Role Description
An exciting and rare opportunity is available for a flow cytometry expert to join the Pharmacokinetics, Dynamics and Metabolism (PDM) Biomarkers/Biomeasures group and influence discovery and translational projects in immunology, inflammatory and genetic diseases. The senior level scientist will be the to-go-to-specialist in flow cytometry within the local PDM team and applies cell biology expertise and deep technical skills to rapidly determine key quantitative, biological parameters that inform mechanistic PK/PD models. Responsibilities include analysis of receptor expression, internalization, turnover and occupancy, signaling and phosphorylation events, cell phenotyping etc. This position also entails acting as the champion for testing and successful implemention mass cytometry (CyTOF). The successful candidate will independently set laboratory objectives, plan laboratory activities and understand as well as influence therapeutic area translational strategies to use biomarkers in scientific decision-making in a matrix environment. Experience in cell based assays, mechanistic pharmacology, target assessment, and translational biomarkers is desirable.
Responsibilities
*The candidate will participate in all phases of flow cytometry laboratory operations including technology evaluations, the development of sample preparation, separation and detection methods, data analysis, interpretation, reporting and follow up discussions with the project teams on utilizing the data in appropriate decision making.
*The successful candidate will have experience developing partnerships in a matrix environment, influencing project strategies, and leadership in technology development and implementation.
*Proactively gathers input from colleagues, teams & management to avoid/address issues at functional level and participates on cross discipline matrix teams
*Excellent oral/written communication skills
*Demonstrated ability to clearly & concisely communicate bioanalytical information.
*Responsible for "fit-for-purpose" assay development and must have the ability to effectively balance assay rigor against resource needs and study goals.
Publications in peer-reviewed scientific journals and external / internal presentations are expected.
Qualifications
B.S. (>8 years), M.S. (>6 years), or Ph.D. (>2-4 years) in relevant scientific field with ideally with industrial experience; Experience in developmen=
t, characterization, and implementation of quantitative bioanalytical assays (e.g., flow cytometry and cell imaging) using wet sample preparation methods and instrumentation.
David C. Anderson | Talent Acquisition | Pfizer Pharma and Bio Therapeutics | 508.656.0580 | Dave.Anderson@Pfizer.com<mailto:Dave.Anderson2@Pfizer.com> | LinkedIn<http://www.linkedin.com/in/davidcanderson> | www.pfizercareers.com<http://www.pfizercareers.com/>
