Dear Flow-ers Users,
Nerviano Medical Sciences (www.nervianoms.com),in Italy in collaboration with other universities and R&D centers is looking for 1 position for "siRNA validation of novel targets relevant to hemato-oncogenesis" founded under 7th FWP (Seventh Framework Programme) in research area FP7-PEOPLE-2011-ITN Marie-Curie Action: "Initial Training Networks".
Before CV application to fabio.gasparri@hemid.eu
<mailto:fabio.gasparri@hemid.eu> please note that candidates must meet following mobility roles of the Marie Curie Action (Curriculum vitae will not comply will not be accepted) :
1. Researchers may be nationals of any country of Europe.
2. Researchers must not have resided or carried out their main activity
in the Country of the host institution (Italy) for more than 12 months
in the 3 years immediately prior to their recruitment.
HEMatopoietic cell IDentity : genetic and epigenetic regulation in
normal and malignant hematopoiesis
Project description
In hematopoiesis, failure to maintain homeostasis and regenerative
functions result in a multitude of hematological malignancies, including
myelodysplastic syndromes, lymphomas and leukemias, that represent a
medical challenge and a large socioeconomic burden because of the large number of affected patients of all age groups. Although hierarchical organization of the hematopoietic system has been well defined in the last years, the precise molecular circuits governing the balance between proliferation/commitment/specification and how these are corrupted in disease are largely unknown.
The focus of Hem-ID is a highly integrated approach to study the
functional interactions between the genetic regulatory circuits
orchestrated by transcription factors TFs-, (that direct the progressive
cell type specification) and epigenetic mechanisms (that establish the
cellular memory that fixes cell fate decisions during differentiation)
in physiological hematopoiesis and in leukemia with the final goal of
formulating novel diagnostic/prognostic markers and therapeutic
approaches in treating leukemias. HEM_ID will:
-Decipher Modular Networks assembled by master TFs controlling
hematopoietic self renewal and differentiation and the molecular
dynamics of TFs/DNA interactions by unique biophysical approache
-Identify epigenetic modifiers (new relevant loci, -epiQTLs,
DNAmethylation, Polycomb dependent-gene silencing, miRNA and long non coding RNAs) involved in the pathogenesis of leukemias.
The strength of Hem-ID ITN lies in the high quality multidisciplinary
-but strictly integrated- expertise and technological platforms covering
the complete pathway from basic research to its clinical exploitation-
contributed from both public Institutions and Private sector and made
available to Hem-ID Fellows. Besides research, an integrated training
program of scientific and complementary activities will be offered to
HEM-ID Fellows that will complement and strengthen their career
development
Research Fields
Biological sciences - Biology
Career Stage
Early stage researcher or 0-4 yrs (Post graduate)
Experienced researcher or 4-10 yrs (Post-Doc)
Research Profile
First Stage Researcher (R1)
Benefits
- 3 year employment contract (junior position)
- 2 year employment contract (senior position)
- Excellent work environment
- Competitive salary (according to the Marie Curie action standard)
- Training in science and complementary skills
- Possible enrolment of the junior fellows in PhD programme run by the
Hem_Id partners.
Comment/web site for additional job details
Requirements
The applicant shall have:
Education
- Master's degree (or any title allowing the candidate to enter a PhD
program in the Country of the Hosting Institution or the Country where
the degree was obtained) in biological or medical science.
- Fluency in English (written and spoken) with an excellent
comprehension level.
Experience:=20
Junior position: Some research experience in lab is preferential but not
mandatory. Candidates with more than 4 years of experience after
