Viability / nuclear stain

From: Sue DeMaggio (suedemag@uci.edu)
Date: Mon Mar 08 1999 - 14:50:06 EST


Has anyone used anything other than PI to do viability staining on the FLOW? 
7-AAD?  

I have a researcher using PI and AO and they co-stain ALL the cells, virtually
100%, in what they believe to be live samples  of Chondrocytes.  Any hints? 
Does the collagenase used to break up the matrix of the cartilage cause
permeabilization?  I'm kind of at a loss to explain to him what is happening. 
Any better dye for this application?

Thanks in advance! 
Susan DeMaggio, MS BSMT(ASCP)QCym 
Resource Manager 
Optical Biology Shared Resource 
University of California, Irvine 
Irvine, CA  92697-2275 
phone   949-824-4110 
fax     949-824-3571 

<http://mamba.bio.uci.edu/~suedemag/OBCore/index.htm>http://mamba.bio.uci.e
du/~suedemag/OBCore/index.htm



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