Hi Emanuel, The population you describe would fit very well with basophils. Basophils are commonly expanded in myeloproliferative disorders. -- Brent Wood MD PhD Director, Hematopathology Laboratory University of Washington Medical Center EM: woodbl@u.washington.edu Phone: (206) 598-6199 Fax: (206) 598-6189 > From: "Emanuel Raniolo" <emanuel.raniolo@imvs.sa.gov.au> > Date: Fri, 4 Oct 2002 10:22:26 +0930 > To: Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu> > Subject: Myeloid populations in myeloproliferative disorders > > > Hi Everyone > > Can anyone fill me in on the identity of a cell population that I have seen > recently in 2 patients with myeloproliferative disorders. > The first patient was a chronic phase CML, the bone marrow of which > displayed a CD45+dim (slightly less than lymphocytes), intermediate side > scatter (less than monocytes) population on CD45/Log SS analysis. This > population represented approximately 3% of all histogram events. The > phenotype was CD13+ CD33+ CD11b+ CD15- CD14- CD34- CD117-. > The second patient (primary thrombocythemia) bone marrow displayed a > similarly positioned numerically smaller population comprising 1% of all > histogram events. This patient was not extensively phenotyped, but again > this population was CD13+ CD34-. > > Has anyone seen these populations previously in their analysis. Do they > represent a mature or immature myeloid population? > > Your responses would be appreciated. Thankyou. > > Emanuel Raniolo > Cell Analysis and Cyopreservation Laboratory > Department of Haematology, IMVS Laboratories > The Queen Elizabeth Hospital Division > Woodville, South Australia. > > >
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