fix first stain later for surface antigens

From: Fishbaugh, Justin (justin-fishbaugh@uiowa.edu)
Date: Mon Nov 25 2002 - 17:26:20 EST


Greetings,

We have an investigator that needs the ability to fix human blood and stain
later for surface and possibly intracellular antigens.   A search of Medline
came up with Jani et al, "Affordable CD4+ T cell counts by flow cytometry
II. The use of fixed whole blood in resource-poor settings," Journal of
Immunological Methods, Volume 257, Issues 1-2, Pages 145-154.  This article
talks about using a fixative called TransFix made by UK NEQAS before
staining.   A search of the UK NEQAS website did not find anything
referencing TransFix.  Does anyone have experience with this stuff or have
some other magic potion that would do the trick?  Thanks.

Justin Fishbaugh
Technical Director
Flow Cytometry Facility
Holden Comprehensive Cancer Center
University of Iowa
48 EMRB
Iowa City, IA  52242
(319) 335-8103 Tel
(319) 335-8049 Fax
http://www.medicine.uiowa.edu/flowcytometry/



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