Re: Instability with large sheath tank

From: Marty Bigos (mbigos@gladstone.ucsf.edu)
Date: Sun Jul 14 2002 - 21:33:31 EST


Gary -

I second Akos's s comment re Cytek. We have two of their systems here
and they work quite well.

The sheath pressure should be approximately 5 psi. If you don't find
any air leaks or problems in the flow system (e.g. you can see a nice
drip into the waste when running), then you might give BD service a
call. The pressure regulator board has been know to fail on these
machines.

Marty

Marty Bigos
Director, Flow Core
Gladstone Institute of Virology and Immunology
Building 3 SFGH Rm 509
415-695-3832

>Gary, sometimes the plastic tanks develop very small leaks that hard
>to detect. Try a new one and see if it makes a difference. We have a
>BD FACSFlow system that can use 20 liters tanks. Great addition to
>the Calibur BUT you can not buy it. They do not sell it in the US.
>Try Cytek (http://www.cytekdev.com). They have a large tank supply
>system for the FACSCan/Calibur.
>
>Best regards, Akos
>Biogen
>
>
>Gary.A.Ward@dartmouth.edu (Gary A. Ward)
>
>05-Jul-2002 10:35 AM
>
>         To:        Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu>
>         cc:
>         Subject:        Instability with large sheath tank
>
>
>
>
>Hello Flow Network,
>
>
>I'm looking for advice from anyone with experience using a FACScan or
>FACSCalibur with a large sheath tank.  We have been experiencing instability
>with our fluorescent signals vs time as well as an apparent decrease in
>fluorescence intensity.  I've checked for air leaks at the tank and believe it
>to be stable.  I've also checked for air bubbles in the Pall filter and tubing
>and these seem to be clear. We routinely clean our system so I don't
>believe it
>to be dirty.  The history of the laser indicates it to be stable. Any other
>suggestions?
>
>
>Also what PSI air pressure are users running with the large tanks?
>
>
>Thank you!
>
>
>Gary A. Ward
>
>H C Englert Cell Analysis Laboratory
>
>Norris Cotton Cancer Center
>
>Lebanon, NH USA


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