Na-heparin / Li-heparin for isolating lymphocytes

From: Frank Mattes (list_server2001@yahoo.com)
Date: Mon Jun 17 2002 - 09:42:45 EST


Dear flow-cytometry reader,

not strictly a flow question. I'm isolating PBMCs from
Li-heparin blood for an ongoing study. PBMCs get
frozen  and stained later for surface markers,
including tetrameric complexes.
In addition I'm using the cells for functional studies
(ELISpots, CD8 response). Because Li-Heparin is used
routinly when collecting blood in our hospital, we
used these type of blood so far. However, someone
mentioned that Li will affect the  funtional capacety
of the cells,and Na-Heparin is superior.

I'm wondering if someone has expirience or had already
compared Li/Na heparin as a preservative.

Many thanks

Frank Mattes
Department of Virology
Royal Free Hospital
London
f.mattes@ucl.ac.uk

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