reagent and cell durability questions

From: maciej simm (flowlab@myflow.net)
Date: Mon Apr 08 2002 - 09:32:19 EST


This is a two parter:

1 - can stained PBMC's be frozen for later analysis? I have people coming in
over the weekend who have to stain their experiments. When I acquire these
in the morning on Monday, they don't look very good (typically 48-72 hrs
after fixing). Is there a way to preserve fluorescence by freezing the
cells?

2 - someone in the lab distributed mucho dollars worth of antibodies for
'future stainings' to 'save time'; of course the antibodies dried up into
colorful little pellets on the bottoms of the staining tubes.

Will these be still usable after mixing them with blood/cell cultures ? or
are there irreversible confirmation changes?

Thanks for any insights.

Maciej

--
Maciej S. Simm
Senior Technologist
Weill Cornell Medical College
Pediatrics Hematology/Oncology
Immunology Laboratory/Flow Cytometry Unit
525 East 68th Street N-805
New York, NY 10021
voice (212)746 3428
fax (212)746 8573
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