True, but there are other CD5-positive lymphomas (mantle cell) that may
mimic splenic marginal zone lymphoma in the blood and are much more
aggressive diseases. That is why I think it is unwise to make a diagnosis
of CD5+ SLVL on a blood sample alone. Rare cases may correlate with
splenic marginal zone lymphoma, but most will not.
____________________Reply Separator____________________
Subject: Re: Re[2]: interesting case
Author: Anja Porwit <Anja.Porwit@ks.se>
Date: 08/02/2000 1:13 AM
Daniel!
Please look up Blood 1994 Mar 15;83(6):1558-62
immunophenotype of splenic lymphoma with villous lymphocytes
and its
relevance to the differential diagnosis with other B-cell
disorders.
Matutes E, Morilla R, Owusu-Ankomah K, Houlihan A, Catovsky D
and several other articles. Both from the literature and our
own experience
there are rare cases that are CD5+ and correlate with the
morphological
diagnosis of SLVL.
Kind regards
Anna
At 12:14 2000-07-31 -0700, you wrote:
>
>I don't think that CD5+ SLVL is a specific pathologic
diagnosis, and is
>unlikely to correlate with a tissue diagnosis of splenic
marginal zone
>lymphoma.
>
> Dan Arber
> City of Hope
>
> ____________________Reply Separator____________________
> Subject: Re: interesting case
> Author: Anja Porwit <Anja.Porwit@ks.se>
> Date: 07/31/2000 4:59 AM
>
>
>
>
> Hello,
> CD5 can be positive in some cases of splenic lymphoma
with
> villous
> lymphocytes - could that diagnosis fit the cytology of
the
> cells in BM? Was
> CD11c positive? Tartrate resistant acid phosphatase?
> Best wishes
> Anna
>
> At 16:24 2000-07-27 -0400, you wrote:
> >
> >We have a case of an 80 year old male, with bone
marrow biopsy
> >showing lymphoproliferative process and enlarged
spleen. The
> bone
> >marrow tumor cells are reported cyclin D1 negative.
The case
> was
> >submitted with a diagnosis of hairy cell. WBC is 2.2
with
> anemia and
> >thrombocytopenia. The peripheral blood is minimally
involved
> (7% of
> >lymphs). The tumor cells are CD19+, CD20 moderate (not
dim),
> CD22
> >moderate, Immunoglobulin moderate- kappa/IgA IgM +,
CD5
> positive but
> >spectrum from dim to moderate, FMC7 + and negative for
CD23,
> CD10,
> >CD103, CD25, CD38, IgD, IgG, and IgE. This doesn't
look like
> CLL or
> >mantle cell. We will be following up on the marrow
biopsy and
> further
> >clinical history and will let you know anything that
pops up.
> Has
> >anyone had a case like this? What is your favorite
diagnosis
> for this?
> >
> >
> > Maryalice Stetler-Stevenson and Doug Kingma
> >Maryalice Stetler-Stevenson
> >Director Flow Cytometry Unit
> >Laboratory of Pathology, NCI, NIH
> >
> Anna Porwit
> Hematopathology Lab.
> Department of Pathology
> Karolinska Hospital, Stockholm
> Anja.Porwit@ks.se
> tel.:+46-851774518
> fax.:+46-851775843
>
>
>
Anna Porwit
Hematopathology Lab.
Department of Pathology
Karolinska Hospital, Stockholm
Anja.Porwit@ks.se
tel.:+46-851774518
fax.:+46-851775843
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