Anna,
I agree with you in the case of marginal zone lymphomas; however, I
hope that you would agree that there are certainly many types lymphoid
neoplasms, including lymphomas, that can be reliably diagnosed and
classified on blood alone.
Dan
____________________Reply Separator____________________
Subject: Re: Re[2]: Re[2]: interesting case
Author: Anja Porwit <Anja.Porwit@ks.se>
Date: 08/03/2000 3:31 AM
Hi,
I do not think that anybody makes a full diagnosis of lymphoma
with
subclassification on a blood sample alone. In our Department in
cases where
there is splenomegaly but no enlarged lymph nodes, a fine
needle aspiration
of the spleen is performed with flow cytometry and/or
immunocytochemistry
on cytospins, bone marrow biopsy with smears and
immunophenotyping is also
done.
Kind regards
Anna
At 08:39 2000-08-02 -0700, you wrote:
>True, but there are other CD5-positive lymphomas (mantle cell)
that may
>mimic splenic marginal zone lymphoma in the blood and are much
more
>aggressive diseases. That is why I think it is unwise to make
a diagnosis
>of CD5+ SLVL on a blood sample alone. Rare cases may
correlate with
>splenic marginal zone lymphoma, but most will not.
>
>
> ____________________Reply Separator____________________
> Subject: Re: Re[2]: interesting case
> Author: Anja Porwit <Anja.Porwit@ks.se>
> Date: 08/02/2000 1:13 AM
>
>
>
> Daniel!
> Please look up Blood 1994 Mar 15;83(6):1558-62
immunophenotype of splenic lymphoma with villous lymphocytes
> and its
> relevance to the differential diagnosis with other
B-cell
> disorders.
> Matutes E, Morilla R, Owusu-Ankomah K, Houlihan A,
Catovsky D
> and several other articles. Both from the literature
and our
> own experience
> there are rare cases that are CD5+ and correlate with
the
> morphological
> diagnosis of SLVL.
> Kind regards
> Anna
>
> At 12:14 2000-07-31 -0700, you wrote:
> >
> >I don't think that CD5+ SLVL is a specific pathologic
> diagnosis, and is
> >unlikely to correlate with a tissue diagnosis of
splenic
> marginal zone
> >lymphoma.
> >
> > Dan Arber
> > City of Hope
> >
> > ____________________Reply
Separator____________________
> > Subject: Re: interesting case
> > Author: Anja Porwit <Anja.Porwit@ks.se>
> > Date: 07/31/2000 4:59 AM
> >
> >
> >
> >
> > Hello,
> > CD5 can be positive in some cases of splenic
lymphoma
> with
> > villous
> > lymphocytes - could that diagnosis fit the
cytology of
> the
> > cells in BM? Was
> > CD11c positive? Tartrate resistant acid
phosphatase?
> > Best wishes
> > Anna
> >
> > At 16:24 2000-07-27 -0400, you wrote:
> > >
> > >We have a case of an 80 year old male, with
bone
> marrow biopsy
> > >showing lymphoproliferative process and
enlarged
> spleen. The
> > bone
> > >marrow tumor cells are reported cyclin D1
negative.
> The case
> > was
> > >submitted with a diagnosis of hairy cell. WBC
is 2.2
> with
> > anemia and
> > >thrombocytopenia. The peripheral blood is
minimally
> involved
> > (7% of
> > >lymphs). The tumor cells are CD19+, CD20
moderate (not
> dim),
> > CD22
> > >moderate, Immunoglobulin moderate- kappa/IgA
IgM +,
> CD5
> > positive but
> > >spectrum from dim to moderate, FMC7 + and
negative for
> CD23,
> > CD10,
> > >CD103, CD25, CD38, IgD, IgG, and IgE. This
doesn't
> look like
> > CLL or
> > >mantle cell. We will be following up on the
marrow
> biopsy and
> > further
> > >clinical history and will let you know
anything that
> pops up.
> > Has
> > >anyone had a case like this? What is your
favorite
> diagnosis
> > for this?
> > >
> > >
> > > Maryalice Stetler-Stevenson and Doug
Kingma
> > >Maryalice Stetler-Stevenson
> > >Director Flow Cytometry Unit
> > >Laboratory of Pathology, NCI, NIH
> > >
> > Anna Porwit
> > Hematopathology Lab.
> > Department of Pathology
> > Karolinska Hospital, Stockholm
> > Anja.Porwit@ks.se
> > tel.:+46-851774518
> > fax.:+46-851775843
> >
> >
> >
> Anna Porwit
> Hematopathology Lab.
> Department of Pathology
> Karolinska Hospital, Stockholm
> Anja.Porwit@ks.se
> tel.:+46-851774518
> fax.:+46-851775843
>
>
>
Anna Porwit
Hematopathology Lab.
Department of Pathology
Karolinska Hospital, Stockholm
Anja.Porwit@ks.se
tel.:+46-851774518
fax.:+46-851775843
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