I don't think that CD5+ SLVL is a specific pathologic diagnosis, and is
unlikely to correlate with a tissue diagnosis of splenic marginal zone
lymphoma.
Dan Arber
City of Hope
____________________Reply Separator____________________
Subject: Re: interesting case
Author: Anja Porwit <Anja.Porwit@ks.se>
Date: 07/31/2000 4:59 AM
Hello,
CD5 can be positive in some cases of splenic lymphoma with
villous
lymphocytes - could that diagnosis fit the cytology of the
cells in BM? Was
CD11c positive? Tartrate resistant acid phosphatase?
Best wishes
Anna
At 16:24 2000-07-27 -0400, you wrote:
>
>We have a case of an 80 year old male, with bone marrow biopsy
>showing lymphoproliferative process and enlarged spleen. The
bone
>marrow tumor cells are reported cyclin D1 negative. The case
was
>submitted with a diagnosis of hairy cell. WBC is 2.2 with
anemia and
>thrombocytopenia. The peripheral blood is minimally involved
(7% of
>lymphs). The tumor cells are CD19+, CD20 moderate (not dim),
CD22
>moderate, Immunoglobulin moderate- kappa/IgA IgM +, CD5
positive but
>spectrum from dim to moderate, FMC7 + and negative for CD23,
CD10,
>CD103, CD25, CD38, IgD, IgG, and IgE. This doesn't look like
CLL or
>mantle cell. We will be following up on the marrow biopsy and
further
>clinical history and will let you know anything that pops up.
Has
>anyone had a case like this? What is your favorite diagnosis
for this?
>
>
> Maryalice Stetler-Stevenson and Doug Kingma
>Maryalice Stetler-Stevenson
>Director Flow Cytometry Unit
>Laboratory of Pathology, NCI, NIH
>
Anna Porwit
Hematopathology Lab.
Department of Pathology
Karolinska Hospital, Stockholm
Anja.Porwit@ks.se
tel.:+46-851774518
fax.:+46-851775843
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