My experience parallels Dan, but I think we are in uncharted waters here and have an
opportunity to do some good science. I would propose that through this website we
establish a registry of CD5+ lymphoproliferative disorder that are not clear cut CLL or
Mantle Cell. I suggest that anyone with such cases send a message to this listserve
and also to the Clinical Cytometry Society c/o Carol Eckenweiler (copied above).
Relevant information should be case number, institution, age and sex of patient, summary
of phenotypic findings (list mode files would be an even greater contribution), clinical
findings and brief history if available, and salient morphologic findings (image files
would be welcome), but to respect good ethical practice no information allowing ready
identification of individual patients (no names or patient ID information) should be
included. Such a data base could be of value in better understanding the specificity
of analytical cytometry in disease diagnosis and classification.
Any support to this idea?
Best regards,
Bruce
Bruce H. Davis, M.D.
Maine Medical Center Research Institute
125 John Roberts Rd., Suite #8
South Portland, Maine 04106
207-842-7914
FAX: 207-761-2130
Email: davisb@mail.mmc.org
>>> "Daniel Arber" <darber@coh.org> 07/31/00 03:14PM >>>
I don't think that CD5+ SLVL is a specific pathologic diagnosis, and is
unlikely to correlate with a tissue diagnosis of splenic marginal zone
lymphoma.
Dan Arber
City of Hope
____________________Reply Separator____________________
Subject: Re: interesting case
Author: Anja Porwit <Anja.Porwit@ks.se>
Date: 07/31/2000 4:59 AM
Hello,
CD5 can be positive in some cases of splenic lymphoma with
villous
lymphocytes - could that diagnosis fit the cytology of the
cells in BM? Was
CD11c positive? Tartrate resistant acid phosphatase?
Best wishes
Anna
At 16:24 2000-07-27 -0400, you wrote:
>
>We have a case of an 80 year old male, with bone marrow biopsy
>showing lymphoproliferative process and enlarged spleen. The
bone
>marrow tumor cells are reported cyclin D1 negative. The case
was
>submitted with a diagnosis of hairy cell. WBC is 2.2 with
anemia and
>thrombocytopenia. The peripheral blood is minimally involved
(7% of
>lymphs). The tumor cells are CD19+, CD20 moderate (not dim),
CD22
>moderate, Immunoglobulin moderate- kappa/IgA IgM +, CD5
positive but
>spectrum from dim to moderate, FMC7 + and negative for CD23,
CD10,
>CD103, CD25, CD38, IgD, IgG, and IgE. This doesn't look like
CLL or
>mantle cell. We will be following up on the marrow biopsy and
further
>clinical history and will let you know anything that pops up.
Has
>anyone had a case like this? What is your favorite diagnosis
for this?
>
>
> Maryalice Stetler-Stevenson and Doug Kingma
>Maryalice Stetler-Stevenson
>Director Flow Cytometry Unit
>Laboratory of Pathology, NCI, NIH
>
Anna Porwit
Hematopathology Lab.
Department of Pathology
Karolinska Hospital, Stockholm
Anja.Porwit@ks.se
tel.:+46-851774518
fax.:+46-851775843
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