Re: IL-2R CD25 vs. CD122

From: Jens Fleischer (jfleischer@knuut.de)
Date: Fri Jun 02 2000 - 05:07:14 EST


Maciej Simm wrote:
>
> Greetings everyone,
>
> This is more genetics than flow, but here it goes:
>
> from my understanding CD25 binds to IL-2R on T cells and CD122 binds
> to IL-2R on NK cells.

My CD chart tells the following:

anti-CD25 reacts with the IL-2 receptor alpha chain, while anti-CD122
reacts with the IL-2 AND IL-15 receptor beta chain.

The common gamma chain for IL-2, IL-4, IL-7, IL-9, and IL-15-receptors
is designated CD132.

However, I have no knowledge whether all three can be visualized on one
cell.

Jens



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