We have a 31 year old female who presented with recurrent, serious bacterial infections. She turns out to be pan hypoglobulinemic with IgG 51; IgA 8.6; IgM 7. WBC is 15,000 with 15% lymphs. In flow she had CD3 36%; CD4 24%; CD8 12%; CD5 40%; CD10 0%; CD19 57%; CD20 61%; CD22 58%; FMC7 23%; there was expression of CD23 and CD25 on about half of the B cells ( CD20 ). There was some very weak expression of kappa and lambda on a few of these cells. Right now that's all I know. >From those of you with experience with immunodeficiency of the non-acquired type, is this consistent with Combined Variable Immunodeficiency. In general, since I have seen so few of these types of cases, I would be interested in any comments. Thanks, Brent Dorsett Lenox Hill Hospital - NYC
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