Hi, CD25 is not normally expressed on B cells in PB. Have you checked CD103 and CD 11c? Even if there is no lymphocytosis the B/T cell ratio in the lymphocyte region is not normal and you see a B cell population that has no clear Ig pattern. How was lymphocyte morphology? ( I'm thinking of hairy cell or NHL with villous lymphocytes that can have only a small population in PB!). Best wishes Anna At 16.35 1999-01-15 -0500, you wrote: > >We have a 31 year old female who presented with recurrent, serious >bacterial infections. She turns out to be pan hypoglobulinemic with IgG >51; IgA 8.6; IgM 7. WBC is 15,000 with 15% lymphs. > >In flow she had CD3 36%; CD4 24%; CD8 12%; CD5 40%; CD10 0%; CD19 57%; >CD20 61%; CD22 58%; FMC7 23%; there was expression of CD23 and CD25 on >about half of the B cells ( CD20 ). There was some very weak expression >of kappa and lambda on a few of these cells. Right now that's all I >know. > >>From those of you with experience with immunodeficiency of the >non-acquired type, is this consistent with Combined Variable >Immunodeficiency. In general, since I have seen so few of these types of >cases, I would be interested in any comments. > >Thanks, > >Brent Dorsett >Lenox Hill Hospital - NYC > > > Anna Porwit-MacDonald Heamatopathology Lab. Department of Pathology Karolinska Hospital, Stockholm anpo@mb.ks.se tel.:+46-851775863 fax.:+46-851775843
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