We have seen CD5 on an ALL. It is not common but can occur. Maryalice >In our experience, we found CD5 expressed on only one of 52 precursor B >and none >of our B-ALLs. Could this be a case of blastic mantle cell lymphoma? > >Dan Arber > >____________________Reply Separator____________________ >Subject: Question on an unusual phenotype of ALL >Author: "Black Emily" <EBlack@providence.org> >Date: 1/8/99 12:34 PM > > >I'm looking to see if anyone is familiar with either the frequency of a >T-cell marker CD 5 on a B-cell ALL or the significance of the >cytogenetics result of a translocated 3,22 in this unusual case. The >patient has no nodal involvement- no lymphoma, but the blood and marrow >are full of young-looking blasts that mark with very mature Bcell >markers-negative for CD 10, CD43, TDT and 34, and positive for CD >19,20,21,22,23,24,FMC-7, LAMBDA monoclonal, and CD 5. Is this CD 5 >positive an unusual occurance that is worthy of publishing or further >study? Maryalice Stetler-Stevenson Director Flow Cytometry Unit Laboratory of Pathology, NCI, NIH
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