In our experience, we found CD5 expressed on only one of 52 precursor B and none of our B-ALLs. Could this be a case of blastic mantle cell lymphoma? Dan Arber ____________________Reply Separator____________________ Subject: Question on an unusual phenotype of ALL Author: "Black Emily" <EBlack@providence.org> Date: 1/8/99 12:34 PM I'm looking to see if anyone is familiar with either the frequency of a T-cell marker CD 5 on a B-cell ALL or the significance of the cytogenetics result of a translocated 3,22 in this unusual case. The patient has no nodal involvement- no lymphoma, but the blood and marrow are full of young-looking blasts that mark with very mature Bcell markers-negative for CD 10, CD43, TDT and 34, and positive for CD 19,20,21,22,23,24,FMC-7, LAMBDA monoclonal, and CD 5. Is this CD 5 positive an unusual occurance that is worthy of publishing or further study?
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