NK leukemia?

From: Rafael Nunez (rafaeln@vetvir.unizh.ch)
Date: Fri Aug 22 1997 - 02:55:25 EST


To
Anna Porwit-MacDonald
>Haematopathology Lab.,
>Karolinska Hospital, Stockholm
and the others Flowers
Anna
If I recall right, you have posted a case about a patient with a likely
leukemia of NK cells, dont you?.
I have some questions relate to this topic. Have you check if the cells
produce Interferon ? by using  intracytoplasmic staining and FACS (finally
a FACS procedure). How are IL-12 levels of the patient?. Can you keep the
cells in culture?, having cell lines of this patient would be great. (I
would love to have one split of the cells for...) My guess is if that
leukemia is a NK cell, you should be able to detect high IL-12 (very, very
high) as well as interferon gamma.
Regards and keep the good job
Rafael


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