Re: Aneuploidy and Polyploidy

Dr Michael Ormerod (mike_o@icr.ac.uk)
Wed, 13 Sep 95 09:31:31 +0100

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Maybe in reply to: David Gebhard: "Aneuploidy and Polyploidy"

We not infrequently observe endoduplication (that is, a tetraploid component
appearing) in cells cultured as suspension cultures. It is important that
the person using the cells realises that they have changed. The lateration
can have a dramatic effect on the properties of the cells. For example, a
cell line which becomes apoptotic on withdrawal of a growth factor, did not
exhibit an apoptotic response in th epresence of tetraploid cells.

The change could be a result of stress if the cells are not being
cultured under optimal conditions.

Michael Ormerod

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu