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From: vtikerpa@rpms.ac.uk
> There is no bona fide "H-Y" antibody - those listed by ATCC are not
> reactive with male cells. Since H-Y antigen consists of a set of
> peptide epitopes, in the binding grooves of MHC class I and class II
> molecules, they are unlikely to elicit antibody responses. The best
> markers for male cells are DNA repeats, of which the Y chromosome is
> liberally endowed in mice and humans. I suggest the following papers be
> consulted:-
> (1) Simpson, E. H-Y and sex reversal: minireview. Cell, 44: 813-814,
> 1986.
> (2) Vollrath, D., Foote, S., Hilton, A., Brown, L.G., Beer-Romero, P.,
> Bogan, J.S. and Page, D.C. The human Y chromosome: A 43 interval map
> based on naturally occurring deletions. Science 258: 52-59, 1992.
>
> (3) King, T.R., Roopenian, D.C., Christianson, G.J., Mitchell, M.J.,
> Bishop, C., Scott, D., Ehrmann, I., Simpson, E. and Eicher, E.M.
> Deletion mapping using immunoselection for H-Y further resolves the Sxr
> region of the mouse Y chromosome and reveals complexity at the Hya
> locus. Genomics, 24: 159-168, 1994.
>
*******************************************************************
*Peter Openshaw p.openshaw@ic.ac.uk *
*Respiratory Medicine Tel:+44 171 723 1252 x 5781/6 *
*St. Mary's Hosp. Med. School Fax:+44 171 724 7349 *
*Imperial College, Norfolk Place, London W2 1PG, UK *
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