Re: luciferase essay using flow cytometer?

From: Richard Haugland (richard.haugland@probes.com)
Date: Wed Dec 04 2002 - 22:02:10 EST


Interesting question. The chemiluminescence peak of luciferin is at
about 560 nm, which is a bit shorter wavelength than phycoerythrin
emssion. Of course, it does not need any excitation to get the emission.
But then, I don't know if the rate of emission will be fast enough to
get enough photons during the transit time that you will be able to
detect the signal. But then S/N should be great because all photons
should be "real." I don't know what technical difficulties there may be
doing sorting with the laser turned off but hope it works.





Nan Jiang wrote:

>Dear all:
>
>I am wondering if anybody ever sorted cells infected with luciferase
>plasmid. Or is there a particular wavelengh we can use to detect
>luciferase activity in cells and sort them based on that.
>
>Thanks in advance.
>
>Nan Jiang
>
>Department of Internal Medicine
>Cardiology Division
>UT Southwestern Medical center at Dallas
>6000 Harry Hines Blvd.
>Dallas, TX  75390-8573
>(214) 648-1175
>(214) 648-1181
>
>
>



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