Hoechst 33342 and cell cycle sorting

From: Steffen Schmitt (FacsLab@uni-mainz.de)
Date: Mon Nov 18 2002 - 09:30:21 EST


Hello flow community,

who has experience with cell cycle staining of viable cells with Hoechst 33342?
The commonly used protocols sound very simple (5-10 µg /ml dye, 30-120 min 37°C). 

My problem are to high CVs for the particular cell cycle stages, so I can´t sort them probaly.
Does anyone know some tricks how to treat the cells (especially Hela cells)? 
 
 Many thanks in advance
 
 Steffen

 ====================
Dr. Steffen Schmitt
FACS Core Facility der Uni Mainz
FacsLab
Obere Zahlbacher Str. 67
55131 Mainz

Phone: + 49 6131 39 30219
Fax:	  + 49 6131 230506
 ====================

www.facslab.toxikologie.uni-mainz.de
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