51 year old man who suffers from epilepsy and takes Tegretal was admitted today because of difficulty in breathing and weight loss. A pharyngeal mass was suspected. He was found to have hepatosplenomegaly and diffuse lymphadenopathy. A routine blood count showed 10 g% Hb, 25,000 platelets and 22,000 wbc with 60% blasts. Flow cytometry: Blast hole (on CD45/SSc dot plots) is about 60% of total nucleated cells and is located at slightly lower side scatter and dimmer CD45 than usual. These cells coexpress CD34, HLA-DR, CD7 (3 subpopulations can be seen), CD5, cyt CD3, cyt 79alpha (dim), CD19, CD33, CD71, CD38 The blasts are negative for: CD2, membCD3, CD4, CD8, CD9, CD10, CD13, CD14, CD15, CD16, Myeloperoxidase, cyt CD68, CD20, Kappa, Lambda, CD36, CD56, CD61, CD64, glycophorin A, CD117, CD133 In addition: DNA histogram shows a small aneuploid peak ( 7% of the blast population) at DI of 1.5 that coexpress CD34, CD7 but lacks HLA-DR. Thanks for your opinions. Judith Chezar
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