[localization within lymphocytes]

From: Lars Brichta (LBrichta@gmx.net)
Date: Mon Sep 23 2002 - 12:55:59 EST


Dear all,

is it possible to determine a protein in lymphocytes (isolated from whole
blood) which is localized in the cytoplasmatic space and the nucleus as well?
I think probably it would be necessary to fix the cells and to use a
permeabilization agent which acts on both the cell membrane and the nuclear membrane
as well?

Does anybody know if there is a paper which gives any hints for such a
method or the use of a kit?

Thanks a lot!

Lars Brichta
Institute of Human Genetics
University Clinics Bonn, Germany


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