[monomeric avidin]

From: Ed Palmer (ed.palmer@unibas.ch)
Date: Fri Aug 16 2002 - 11:27:49 EST


Dear Fellow Flowers,

Does anyone have any information about monomeric avidin? (or monomeric
streptavidin) i.e. an avidin that can bind just one biotin molecule?  We
are constructing a ligand for a T cell surface molecule which will have
one biotin molecule attached.  If there was a streptavidin-PE conjugate
available that could bind just one biotin, then we might be able to
accurately quantify how much ligand was bound using flow cytometry.

Thanks for any information you might have.

Ed Palmer
______________________
Ed Palmer M.D. Ph.D.
Laboratory of Transplantation Immunology
and Nephrology
Department of Research
University Hospital-Basel
Hebelstrasse 20
CH-4031 Basel, Switzerland
e-mail: ed.palmer@unibas.ch
FAX: + 41 61 265 34 20



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