newbie help with software compensation

From: Frank Mattes (list_server2001@yahoo.com)
Date: Wed Jun 12 2002 - 06:01:57 EST


Dear Flow Cytometry list reader,

as a disclaimer, I'm quite new to the FCS techniques,
and hoping not to upset anyone with my question. I
looked through the archive but couldn't find a answer.

I just discovered the the software package "Summit"
form Cytomation, which is "free" to use as a offline
analysing tool. I was surprised to read the following
statement in the online tutorial:

" By using the Summit software, there is no need to
adjust compensation on the
cytometer before acquiring data. Summit provides the
ability to adjust compensation after the
raw data has been acquired and saved as a file"

What is your opinion to this statement ?. Is this true
?.
FlowJo, FCSPress also give the possibility to
"software" compensate samples. Will I get the same
result when I do the compensation with these packages,
or will the result depend on the underlying
algorithmen ?.

I appreciate if anyone can comment on my questions.
I'm also interested to know if someone knows review
articles on compensation/how to do (software and
hardware).

Many many thanks

Frank Mattes
PhD student
Royal Free Hospital and University College Medical
School
London
f.mattes@ucl.ac.uk

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