Breast CA DNA ploidy index of 0.41

From: Bessie Kam (bkam@dls.queens.org)
Date: Tue Oct 30 2001 - 13:50:50 EST 

Hi,
Has anyone ever seen a breast cancer DNA Index of 0.41.  We have a
multiploid patient that shows DI of 0.41 (about 20% of the population ,
0.82 (about 3% or so) 1.0 (about 20%), and 1.91(about 50%).  I have never
seen a hypodiploid that low.  I am not sure what the 0.41 and 0.82 mean...
looks like it could be a cycling population.  CVs for the peaks are 2% or
less.  We confirmed the diploid population by adding back lymphocytes.
Testing was done on frozen tissue with Krishan's PI reagent.

I will follow up with image analysis and see how that goes, but I would
like to know if anyone has seen a hypodiploid like this.

thanks for the input
bessie
--
Bessie Kam                                Email: bkam@dls.queens.org
The Queen's Medical Center, Pathology     FAX:   808-547-4045
                                          Phone: 808-547-4271

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