Thanks for bringing this subject up, Cy. I wouldn't be keen to diagnose lymphoma on such a small sample size. It is my understanding that (histologically) the cerebral lymphomas encountered in HIV positive patients grow around the blood vessels in the brain and there is not much spill-over into the CSF. I have been involved with a few of these specimens and in all cases have reported "insufficient cells." What are others experiences with such samples? CSF specimens that have yielded sufficient cells in my hands have been collected from patients with leukaemia. Paul Paul Homes Immunology Mayne Health Western Diagnostic Pathology 74 McCoy Street Myaree Western Australia 6154 paul.homes@maynegroup.com Phone: (08) 93170920 Fax: (08) 93170913 -----Original Message----- From: cy [mailto:ooncy@pacific.net.sg] Sent: Sunday, 14 October 2001 16:03 To: cyto-inbox Subject: CSF Hi everyone, We received a CSF specimen for flow. Cell count was 5/ul. The sample was from a lymphoma patient with HIV positive. The physician would like to know if CSF was involved. We acquired as much cells as possible but the number of CD45 positive cell was still very low (87 events). About half of them (36 events) were CD19+ B-cell. Of these, 29 events were positive for kappa. How significant are these numbers? Would you call this CSF involvement with kappa restriction? How would you have reported this? Your opinion will be very much appreciated. Thanks. cy ********************************************************************** This email and any files transmitted with it are confidential and intended solely for the use of the individual or entity to whom they are addressed. If you have received this email in error please notify the system manager. This footnote also confirms that this email message has been swept by MIMEsweeper for the presence of computer viruses. **********************************************************************
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