Re: Receptor toxicity?

From: Tim Kute (tkute@wfubmc.edu)
Date: Wed Jun 27 2001 - 08:36:43 EST


Interesting story.  What receptor were you transfecting in.  In some cases, the antibody
might activate a death response.  This happens with HER2/herceptin.

Tim Kute

JASON MCCORMICK wrote:

> Hello all.
>
> Has anyone out there had the experience of a transfected-in surface receptor inducing
> post-sort death?
> Got a cell line which is just peachy for shoving in other, quasi-related surface
> receptors, but it doesn't seem to like this one.  The pre-sort viability is okay (>80%
> even at high culture density), but after staining, washing, sorting, the viability
> drops to less than 1%.  Have verified that sort recovery is good by counting (oh,
> my aching retinas), but the darn things just die.
>
> Any ideas?
>
> Thanks in advance,
>
> Jason




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