Hi John, We recently had a 10 yr old female who presented with similar haematology as your patient. She had a WBC count of 70 - 80 x 10 9/L with hypereosiniphilia (PB & BM), and approx 15 % progenitor cells in BM (ie: CD10+, CD19+, Tdt+ which appeared to be hematogones). Our patient was originally admitted for breathlessness & diffuse shadowing on chest X-ray. Neurological symptoms subsequently developed and she was treated with high dose steroids with a good response while investigations continued. Acute lymphoblastic leukaemia with eosinophilia, although rare is a distinctive clinical entity and well described in the literature. The eosinophilia in these patients can present before, concomitantly, or after the diagnosis of leukaemia. Patients with this syndrome seem to have cytogenetic abnormalities particularly involving t(5;14)(q31;q32). Our patient has not shown any chromosomal abnormalities, however, IgH gene rearrangements by southern blot demonstrated a distinct clonal band. PCR was performed on BM samples on several occasions and shown polyclonal populations - family primers were used which may have masked this small clone. Currently, our Paediatric Oncologist & Haematologists are reluctant to treat this child with chemotherapy so were are playing a waiting game to see what may develop. Incidentally she remains well on steroids which are keeping the hypereosinophilia under control. Regards, Glennis White Haematology Laboratory Capital Coast Health Wellington New Zealand glennis.white@wnhealth.co.nz ----- Original Message ----- From: JOHN MARIO GONZALEZ _ PROFESOR DPT. MICROBIOLOGIA-. <jmgonzal@javeriana.edu.co> To: cyto-inbox Sent: Thursday, March 29, 2001 9:16 AM Subject: Hematogones > > > Recently. It was a nice discussion about hematogones (CD19+, CD10+ > CD34+). We have an interesting case of 10% of hematogones in a 23 years > old girl. She has 70,000/ul WBC, 80% of eosinophils. MB is also full of > eosinophils. > > Any comment? > > JOHN MARIO GONZALEZ M.D., Ph.D. Facultad de Ciencias Pontificia > Universidad Javeriana Phone 00 571 2850503 Fax 00 571 3208320 Ext 4085 > > >
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