with time, geometric mean increases?

From: Maciej Simm (simmmmer@yahoo.com)
Date: Tue Mar 13 2001 - 13:17:53 EST


Dear group,

I had an unusually large batch of monocyte cytokine stains to do
yesterday, and the acquisition took a lot longer than usually. Long
enough, in fact, to notice that between the control sample (acquired
at time=0) and the last patient (acquired at time=3.5 hrs) CD33 FITC
and CD45PE-Cy5.5 signal went up by half a log.

The samples were fixed and washed multiple times so there's no way
there was any free antibody left to "add" more signal.

Why did the signal go up so much?

The unstained, external and internal isotype stains were unaffected.

Any thoughts would be appreciated,

Maciej

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