Hematogones are classically described in the bone marrow, at all ages. There may be circulating hematogones in the peripheral blood of neonates. Circulating CD10+ CD19+ CD34+ cells circulating in the blood in a patient past the neonatal period might represent leukemic blasts. CD10+, CD19+, surface light chain negative cells in a lymph node represent follicle center cells and might be lymphoma; stains could be done for bcl-2. Tim Singleton, MD William Beaumont Hospital Royal Oak, MI >>> sterling stoudenmire <sstouden@thelinks.com> 02/07/01 08:55PM >>> andrea, some of these markers might be specific to the location from which the sample was taken? any comments on that issue? sterling At 01:12 PM 2/5/01 -0500, Andrea Illingworth wrote: > Another question for the flow experts: of B-cell differentiation: >CD45 dim, very low FALS Pop#2: CD19+, CD10+ (a little weaker than the >first pop.), CD34-, weak CD20 and CD22, no k/l, CD45 ( a little brighter >than pop 1), very low FALS Pop#3: CD19+, CD20+ (bright), CD22+ (bright), >polyclonal kappa and lambda, bright CD45+ Which ones are the >hematogones, only the first population or is the second population >(CD10+,CD34-) also called hematogones? What is the definition of >hematogones? Are they always CD34+? 1 and 2, they seem to "jump" from >being CD34+ to being CD34 negative without the stages in between. Thank >you for any insight Andrea Illingworth DCDS Flow Cytometry Bangor, Maine Computer Aided Cell and Molecular Biology (CACMB), not medicine, will find the cure for cancer and other diseases. There will always be a need for the trained clinician (MD/RN) but, advanced diagnostic and treatment option selection has become gene based, has moved from the physician's practice to the computerized cell and molecular biology laboratory, and appropriate treatment options should now be based on the personal biology of the patient.
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