RE: in case of isotype control - substitute?

From: Hodge, Greg (HAEM) (hodgeg@mail.wch.sa.gov.au)
Date: Mon Oct 30 2000 - 16:19:27 EST


> ----------
> From:		Maciej Simm
> Sent:		Tuesday, 31 October 2000 1:17
> To:	Cytometry Mailing List
> Subject:	in case of isotype control - substitute?
>
> Maciej,
>
>      I dont bother with isotype controls for IL-10 production by
> monocytes, I find unstimulated monocytes do not make any IL-10 and so use
> this as my "negative" control.
>
> Greg Hodge PhD
> hodgeg@mail.wch.sa.gov.au
> --------------------------------------------------------------------------
> ----------------------------------------------
>
> On 31 October, Maciej wrote-
>
> Howdy Everyone,
>
> I am running IL-10 in human monocytes using a PE conjugated Rat anti
> Human IgG1 antibody. There is a shortage of intracellular isotype
> control for that. What can I use instead? someone recommended using
> anti rat IgG2 etc.. but I've read on here earlier the 2's are picked
> up by monocytes..
>
> so how about a mouse IgG1?
>
> Maciej
>
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