Dear Flowers, I've come across a leukaemia case of CD45 dim or maybe negative expression. Have any dear friends got experience on this kind of cases? We've done the 3-color immunophenotyping, using SS/CD45-PC5 as the gating stretegy. The gated population on bone marrow specimen has positive expression of CD19, CD10, HLA-DR, CD13, CD34; negative expression of CD14, CD3, CD5, CD7 and sIg. Weak expression of CD13 was also observed. We're waiting for the t-dT result by immunohistochemical detection. Would you consider these findings are case of biphenotyping leukaemia or ALL with abberrant expression of myeloid marker?? WK LEE
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