Hello,
B-precursor ALL are often CD45dim or negative. The most probable diagnosis
is B-precursor ("common") ALL with aberrant CD13 expression - you will need
positive TdT result to confirm.
Best wishes
Anna
At 10:28 2000-08-19 +0800, you wrote:
>
>Dear Flowers,
>I've come across a leukaemia case of CD45 dim or maybe negative expression.
>Have any dear friends got experience on this kind of cases?
>We've done the 3-color immunophenotyping, using SS/CD45-PC5 as the gating
>stretegy. The gated population on bone marrow specimen has positive
>expression of CD19, CD10, HLA-DR, CD13, CD34; negative expression of CD14,
>CD3, CD5, CD7 and sIg. Weak expression of CD13 was also observed. We're
>waiting for the t-dT result by immunohistochemical detection. Would you
>consider these findings are case of biphenotyping leukaemia or ALL with
>abberrant expression of myeloid marker??
>
>WK LEE
>
>
Anna Porwit
Hematopathology Lab.
Department of Pathology
Karolinska Hospital, Stockholm
Anja.Porwit@ks.se
tel.:+46-851774518
fax.:+46-851775843
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