Set up for Hoechst cell cycle analysis

From: Natasha Webb (natasha.webb@csc.mrc.ac.uk)
Date: Mon Jun 12 2000 - 05:46:38 EST


Dear Flow group,

I am currently having problems setting up a FACS Vantage for Hoechst Cell
cycle analysis.  It has an Innova 70 laser with UV maximum at 50mW.  I
would like to know what beads or set up methods others have used to
optimise the settings to get tight CV's.  I have tried using UV beads from
Molecular Probes and then Calf thymus nuclei from the BD DNA QC particles
box with 5 ug/ml Hoechst, however, I cannot get any decent looking cell
cycle phases - I can only presume there are better methods than this
attempt.  If anyone has any suggestions, it would be much appreciated.

Regards
Natasha.

Natasha Webb

Assistant Flow Cytometry Operator
Room 5027
Clinical Research Building
Hammersmith Hospital
London

Phone:  0181 383 8330



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