Signal detection and sensitivity

From: Robert Adair McGilp (rmcgilp@rics.bwh.harvard.edu)
Date: Thu May 25 2000 - 13:51:32 EST


Hello all,

I would like some input regarding an issue I should probably be able to
answer, but ...
I have an investigator who has been using a FACSort to analyse his FITC/
PE/Cychrome labelled samples and gets good resolution of the populations
of interest (dual positives). He feels that we have been unable to
reproduce the results on our Vantage SE. We have moved the z axis so that
the nozzle is a good inch above the laser intercept and this gives a good
approximation of the results he has seen on the analyser. I have no
problems with other samples and the sorter is performing very well. Is
there something I can do to increase the sensitivity without rearanging
the entire laser set up? The laser involved is an Enterprise II, with the
primary power (UV) set to 25mW. This gives approx 300mW of 488 line.

Thanks in advance,

Rob McGilp
Center for Neurologic Diseases
Harvard Institutes of Medicine.
Boston MA


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