Dear Andrea,
we also have found some CD4+CD8+ double positive lymphocytes in a lot of
probes from human pb via flowcytometry. For my knowlegde these cells are
normal lymphocytes which are exported from thymus where in selection
processes some mistakes occurs, resulting in some 4/8 double positive
cells.
>From our experience these cells are rising up after activation of the
immunsystem, like and paralleled by CD3+HLA-DR+.
For example we have the following numbers in peripheral blood
lymphocytes of controll adults and ENT-Cancer patients in CD4+/CD8+
lymphocytes (%; U-Test):
Control : 2,38 (n=32)
p= 0.002
Patients with acute cancer : 4,19 (n=73)
p= 0.003
Patients after therapy and
cured : 2,97 (n=112)
p= 0.04
Patients with recurrence : 4,25 (n=30)
My be, this is helpfull for you.
J.Ostwald
ENT-Clinic
University Rostock
Germany
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