Dear Flowers, We got a peripheral blood sample with a clinical diagnosis of B-CLL. The leukocyte number is 40000, and 83% of cells are lymphocytes. We found that the majority of cells were positive for CD19, CD5, CD22, CD23 AND CD8. These are the results in the lymphocyte gate: CD45+ = 99,8% CD14+/CD45+ = 0,3% CD19+ = 91% CD19+/CD5+ = 90,5 ! CD19+/CD8+ = 86,7% CD20+ = 11,5% CD21+ = 12,7% CD22+ = 93,7% CD23+ = 84% CD3+ = 5,6% CD3+/CD4+ = 2,5% CD3+/CD8+ = 3,8% CD7+ = 5,3% HLA-DR+ = 93,6% We found some articles in Medline with this aberrant CD8-expression: Brunet-C; Bardin-N; Oukhouya-O; Harle-JR; Zattara-Cannoni-H; Dignat--George-F; Sampol-J: A case report: CD8 expression in B-cell chronic lymphocytic leukemia (B- CLL). Prognostic significance of the aberrant CD8 expression. Hematology-and-Cell-Therapy. 1998 015 01; 40/6 (279-282). Fernhout-F; Dinkelaar-RB; Hagemeijer-A; Groeneveld-K; Van-Kammen-E; Van-Dongen-JJM: Four aged siblings with B cell chronic lymphocytic leukemia. Leukemia. 1997 td0 01; 11/12 (2060-2065). Avila-Carino-J; Lewin-N; Tomita-Y; Szeles-A; Sandlund-A; Mosolits-S; Mellstedt-H; Klein-G; Klein-E : B-CLL cells with unusual properties. International-Journal-of-Cancer. 1997; 70/1 (1-8). My question is if you have experience in this rare type of B-CLL? Any comment or help would be greatly appreciated. Julia Julia B. Szeberenyi M.D Dept. of Genetics, Cell-and Immunobiology Laboratory of Flow Cytometry Semmelweis University of Medicine H-1089 Budapest, Nagyvarad ter 4 Hungary email: szebjul@net.sote.hu fax:+36-1-303-69-68
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