Re: Interpretation of antigen expression

From: Maciej Simm (simmmmer@yahoo.com)
Date: Fri Oct 12 2001 - 22:29:12 EST


In my humble opinion, it is impossible to tell dims from brights
unelss both are present. If there is one smear of positive cells
spanning a large log range (ex. CD69 expression, inf-gamma etc) that
ranges from isotypic cutoff to high 3rd log, I would not call part of
that dim and the other bright.
I would only talk about dim and bright in cases like CD8 or CD56 on
lymphs - where both populations are usually present and can be
clearly distinguished on a histogram.

Maciej


> 2. How /  What are the criteria to define the dim, intermediate or
> strong antigenic expression? For example: dim for those overlapping
> the isotopic cutoff, intermediate for those behind the isotopic
> cutoff and strong for those with 2 log scale of the isotopic
> control.


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