CD45RA , CD45RO expression on T cells

From: Mark Winter (m@winter55.freeserve.co.uk)
Date: Sat Jul 07 2001 - 07:13:37 EST 

Hello Flowers,

I'm looking at CD45RA and RO expression on CD4 and CD8 T cells. Could
somebody confirm for me whether these markers are mutually exclusive
regarding their expression upon the cell membrane? I know that the naive
cells are CD45RA+ and the CD45RO+ cells are memory cells, but is it possible
to have double positive CD45RA+CD45RO+ T cells, or double negative
CD45RA-CD45RO- T cells?
If so, what percentages would be expected in the peripheral blood?


I would love to have a reply from somebody in the know!

Thanks,
Mark

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