rare event

From: Qi, Hai (haqi@utmb.edu)
Date: Wed Dec 01 1999 - 17:49:23 EST


It is really not too rare, a cell population about 0.04% to 0.15%, while the
background is 0.01-0.05%. The problem is the variation among different
measurements, presumably due to the systematic error. For example, I had
10e7 total cells and ran 2*10e5 out of them for two times: one time I got
0.04% and the other time I got 0.15%. In order to have smaller variation,
obviously I have to increase my sample size, but the last thing I want to do
is to run through all 10e7 cells. Can anyone give me a handy statistical
method for estimating the sample size that makes a cost-effective
compromise? Thank you very much.

Hai Qi
Dept. of Pathology, UTMB



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