I have an interesting/puzzling case for the group. A 16 month old Female, (non-Downs) was diagnosed with M7 seven weeks ago. She was not doing well on therapy and we got the case. Her morphology shows large blebbing blast-like cells but her cytogenetics look very pre B-ALLish, WBC is 3.2X10^6/mL. Her flow is as follows: Positive for CD38, CD42a, CD56 and CD117 Partially/Dimly positve for CD33 and CD61 Negative for CD3, CD4, CD5, CD7, CD8, CD11b, CD13, CD14, CD15, CD16, CD19, CD20, CD34, CD95, Kappa, Lambda, TdT, MPO and HLA-DR There also is a population of about 0.5% of the BM that is CD10+CD22+ (pre B-ALL fraction of two clones?) which falls in the same CD45vs.SSC gate but seems negative for all other markers. Any ideas? Brian Newsom Director, Flow Cytometry Center for Cell and Gene Therapy Baylor College of Medicine
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