Yeast and Flow

From: Walker, Don (donwalker@chiroscience.com)
Date: Wed Aug 18 1999 - 16:21:59 EST


Hi,

	I have a user that wants to start running yeast on the flow
cytometer.  I have some trepidation about this.  I have heard a variety
of good, bad and ugly comments about this area.  I know there are some
experts in this area out there in FlowLand.  My main concern is the
procedures needed afterwards to insure that no contamination occurs in
subsequent sorts of mammalian cells.  Do people who do yeast dedicate an
instrument just for that? ( food and beverage industry )? One thought,
without knowing how Herculean the cleaning efforts are, is to dedicate a
separate sample line just for yeast. What chemicals, fungicides etc. do
you yeast/flow experts out there use?  Do you  recommend periodic
cultures of the stream to test if the cleaning procedures are adequate?
I'll share a short summary, with the list, of any responses I receive.
TIA for your help with this.

Sincerely,
Don Walker



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