cd3-cd4+cd30+ ?LEUKEMIA

From: robert gniadecki (rgniadecki@hotmail.com)
Date: Sat Aug 14 1999 - 14:00:50 EST


Hello everybody!
I am currently treating a patient with total skin inflammation 
(erythroderma). We suspected Sezary's syndrome, so we performed flow. We 
found the following phenotype:
CD3-CD4+CD8-CD30+CD45RO+
negative for CD25,26,27,28,29,CD45RA
Peripheral blood is normal which excludes the anaplastic large cell 
lymphoma/leukemia. Skin biopsy did not show any leukemic/lymphoma cells, 
though few, normal CD30+ lymphocytes were present.
What is the diagnosis?
Has anybody seen such a phenotype before??
Any input will be appreciated.

Regards,
Robert Gniadecki, MD, PhD, DMSci
Dermatology, University of Copenhagen
Denmark


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