Re: Apoptosis

From: Mark A. KuKuruga (kukuru@umich.edu)
Date: Thu Apr 01 1999 - 13:22:16 EST


Girakhoo, Soheila wrote:

> Hi
> Could somebody suggest me about apoptosis satining with Annexin V-FITC and PI
> for Flow Cytometry ?
> I want to stimuli my cells befor staining with DEX, etopside, Staurosporine,
> Actinomycin D.
> Thanks, Soheila
>

There's plenty of literature available on this application . . . do a search on
annexin V and flow cytometry.  This will result in a wealth of info that will
include your apoptosis inducers.  As a beginning, I usually start with the
following:Darzynkiewicz Z, et al.  Cytometry in Cell Necrobiology: Analysis of
Apoptosis and Accidental Cell Death (Necrosis).  Cytometry 27: 1-20 (1997)
You can also check with reagent suppliers (PharMingen, Phoenix Flow Systems . .
. Coulter and Caltag, too, I think . . .).  Their reagents will come with
detailed procedures for labeling.


--
Mark A. KuKuruga, Managing Director
University of Michigan Core Flow Cytometry
kukuruga@medmail.med.umich.edu



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