On Thu, 18 Mar 99 09:31:58 PST, Tom Mc Closkey wrote: >Our division saw a patient yesterday with a n extremely low CD8 T >cell count (200 CD8s/ul), an 11 year old who has experienced recurrent >infections. From the leterature I have found 2 defects which affect the 8s: >comments are greatly appreciated. Over the years I've seen a number of such patients. Consistent finding was the absence of bright CD8 cells, while dim CD8 / NK cells persist. All except for one clinically presented as severe combined immunodeficiencies. The single patient with exactly the same phenotype, yet only marginally immunodeficient (if at all) was a girl then of ca 8 years. For a CD3gamma defect I'd anticipate lower levels of CD3 as well. Martin R. Hadam Kinderklinik - Medizinische Hochsch>ZAP70 results in complete absence of 8s and CD3 gamma defect which >results also in absence of CD4 CD45RA cells (RA is normal), neither of >which seem to fit. Has anyone seen anthing like this? Any thought s or ule D-30623 Hannover Germany Email: Hadam.Martin@MH-Hannover.de
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