Our division saw a patient yesterday with a n extremely low CD8 T cell count (200 CD8s/ul), an 11 year old who has experienced recurrent infections. From the leterature I have found 2 defects which affect the 8s: ZAP70 results in complete absence of 8s and CD3 gamma defect which results also in absence of CD4 CD45RA cells (RA is normal), neither of which seem to fit. Has anyone seen anthing like this? Any thought s or comments are greatly appreciated. Thanks, Tom -------------------------------------------------------- Thomas W. Mc Closkey, Ph. D. Director, Flow Cytometry North Shore University Hospital Biomedical Research Center 350 Community Drive Manhasset, Long Island, New York 11030 ph: 516-562-4844 [office]; 516-562-1135/4641 [lab] fax: 516-562-2866 3/18/99 9:37:29 AM E-mail: thomasm@nshs.edu --------------------------------------------------------
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